« Viagra For Women – Your Ultimate Guide | Home | What Would Happen If Lsd Came In Direct Contact With A Human Brain? »
Methadone: to Take Or Not to Take This Anti-narcotic Drug
KNOWING METHADONE
Methadone is an Opioid. Methadone is synthetic by nature. Methadone is also an analgesic. Methadone is basically recommended for the chronic drug abusers. Methadone has been found to be an ideal medication for the treatment of addiction from narcotic substances. Of late, methadone has been widely recommended for patients suffering from chronic pain. Methadone’s effective action remains for long duration. Moreover, Methadone is quite cheap as well. As per the Single Convention on Narcotic Drugs, methadone is included in the list of Schedule II drug.
METHADONE METABOLISM
There are two reasons as to why Methadone effects last longer than other morphine drugs. First, methadone’s lipid solubility is quite high. Second, methadone metabolism is slow. Most importantly, the dependence incidence of patients is low. Hence, there is less danger of a heroin detoxified patient treated on methadone getting hooked to the synthetic opioid. Methadone keeps intact the analgesic effects from a day to two at the most.
IDEAL FOR DE-ADDICTION UNITS
Methadone is ideal for the de-addiction units particularly because of the life of a methadone dosage. Moreover, methadone can be given by injection or even orally. For instance, a single daily dose of methadone is enough to keep under control any heroin addict for the entire day.
TOLERANCE & DEPENDENCE OF METHADONE
The tolerance and dependence of methadone increases as one keeps on taking more doses of the synthetic opioid. In this aspect, methadone is similar to heroin. However, the tolerance factor as well as the effects (physiological) differs. Still, it has been found that methadone leaves no tolerance to constipation. However, the other opioids do leave tolerance effects on the patients especially with respect to constipation. Mentionably, analgesia tolerance appears in the first month after one starts taking the drug. But, tolerance to nausea, sedation and respiratory depression commences within four days after one takes such medications.
METHADONE & NDMA
There is a close link between methadone and the brain receptor known as NMDA (N-methyl-D-aspartic acid). Methadone can even control tolerance and psychic dependence. This is possible because of its strong reaction against opioid. It is due to this reason that patients taking methadone exhibit lesser withdrawal symptoms than those who are into heroin or morphine. Nonetheless, the methadone withdrawal symptoms linger more than the latter.
THE METHADONE LAUNCHER
Methadone was commercially launched by Eli Lilly and Company, a pharmaceutical company.
THE INVENTORS OF METHADONE
German scientists Methadone Gustav Ehrhart and Max Bockm
Leave a Comment